Endocrine Abstracts

Introduction: Tendency to store lipids centrally is well connected to development of diabetes mellitus type 2 (T2DM) and cardiovascular morbidity. Providing insight in this process is important.Method: Relationship between radius of waist line and thickness of subcutaneous adipose tissue (SAT) was compared among forty obese patients (BMI> 30 kg/m2) in the light of their glycemic control parameters (fasting glucose, HOMA IR, HOMA beta).Pati...

Introduction: Hormonal syndromes are significant cause of morbidity in patients with neuroendocrine tumors (NET), requiring special treatment, rarely completely efficient. Effect on mortality is also presumed. Our aim was to investigate epidemiological characteristics of NET with hormonal production in our group of patients.Patients and methods: We analyzed 822 patients with NET of various primary tumor sites, treated at our department during period of 2...

IntroductionHypogonadism is a potential manifestation of many chronic diseases including cancer, presumably related to their severity. Since novel anti-cancer treatments have significantly increased survival rates of affected patients, issue of hypogonadism becomes more significant, given the importance of issues like quality of life and potential for reproduction. The aim of our study was to analyze gonadal axis function in male patients with neuroendoc...

Background: While a considerable body of literature exists detailing outcomes in patients with adrenocortical carcinoma (ACC), reports specifically addressing a cohort of patients with recurrent disease remain scarce. Therefore, the objective of this study was to evaluate treatment outcomes in patients with recurrent ACC.Methods: In our cohort of 55 patients who underwent R0/Rx tumor resection between 2011 and 2022, 18 individuals (33%) exhibited recurre...

Background: Alpelisib is a novel phosphotidylinositol 3-kinase (PI3K) inhibitor which, in combination with fulvestrant, has been shown to increase progression-free survival in patients with HR+/HER2-/PI3KCA mutated advanced breast cancer[1]. Hyperglycaemia, including alpelisib-induced diabetic ketoacidosis is a known adverse effect, along with rash, diarrhoea and stomatitis. No other associated endocrinopathy has been reported to date. Case presentation: We present th...

Background: Pancreatic Neuroendocrine Neoplasms (pNENs) are malignancies arising from the endocrine pancreas. Past in vitro studies have led to a better comprehension and characterization of this malignancy under several points of view. However, effective medical therapies are still not available, therefore, it is essential to continue studying this malignancy in order to identify a successful approach. Due to tumour complexity, techniques such as 3D cultures, able to...

Background: SIADH is the most frequent underlying cause of hyponatraemia but is frequently ignored and suboptimally treated.Aim: To identify the treatment applied in clinical practice for hyponatraemia due to SIADH and to evaluate the effect of fluid deprivation.Method: A prospective, non-intervention observational study of a sequentially evaluated cohort of hyponatraemic patients during first 48 h after hospitalization from Januar...

Introduction: The management of type 1 diabetes (T1D) in young children can be extremely challenging due to high insulin sensitivity, unpredictable eating and activity and difficulty recognizing symptoms of hypoglycaemia. Continuous subcutaneous insulin infusion (CSII) therapy is beneficial in managing young children, however the small insulin doses required challenge the accuracy of standard concentration (100 IU/ml) CSII.Case report and literature revi...

Introduction: The incidence of obesity and other features of the metabolic syndrome is increased in shift workers. This may be due to a misalignment between the internal circadian rhythm and the behavioral rhythm. The stress hormone cortisol could play a role in this phenomenon, because it is secreted in a circadian rhythm, and long-term elevated cortisol levels leads to components of the metabolic syndrome. Our aim was to study changes in long-term cortisol levels due to shif...

Increases in proinflammatory pathways and macrophages in adipose tissue (AT) have been implicated in the metabolic complications of obesity (1). Nutrient-restriction (NR) in early to mid gestation reduces maternal plasma cortisol and increases fetal AT (2). Uncoupling protein (UCP)-2 is genetically linked to obesity and type 2 diabetes, and has been implicated in macrophage-mediated immunity. The effect of maternal NR in early to mid and late gestation on UCP2 and glucocortico...